Department of Natural Sciences/University of Maryland Eastern Shore

The overall goal of our research program is to understand the mechanisms that govern fluid and solute transport in the vertebrate kidney.


Insulin signaling and renal epithelial transport

Epithelial cells that line the renal proximal tubule reabsorb a significant fraction of filtered sodium and water, and therefore, play a key role in regulating body fluid osmotic homeostasis.  The sodium proton exchanger 3 (NHE3) is expressed in the proximal tubule and accounts for the majority of total Na+and water epithelial transport.  Any changes in NHE3 activity can greatly impact body fluid osmotic homeostasis and alter cellular functions.  Thus, NHE3 is a tightly regulated transport protein. Similar to NHE3, insulin receptors are expressed along the renal tubule of the mammalian kidney with a higher density in the proximal tubule.  Importantly, insulin was shown to stimulate Na+and water epithelial transport in this segment via increased NHE3 activity.  However, despite extensive research efforts, little is known about how insulin activates NHE3. Our laboratory uses the zebrafish as a model organism to study the signaling mechanisms that link insulin to an increase in proximal tubule-specific sodium proton exchanger 3 activity.

We are located on the first floor of Carver Hall.  Come see us in room 1125.

Carver Hall-Lab


Research is supported by the National Science Foundation (NSF).